Six American grad students have arrived in Africa to study apes with a renowned professor. But after setting up camp in a jungle clearing, they soon become witness to the carnage inflicted by the strange and remote species.

In 1993, estranged Street Fighters Ryu and Ken Masters are thrown back into combat when the mysterious Chun-Li recruits them for the next World Warrior Tournament: a brutal clash of fists, fate, and fury. But behind this battle royale lies a deadly conspiracy that forces them to face off against each other and the demons of their past. And if they don't, it's GAME OVER!

一队背包族起程到丛林中去探险，其中的一员被一只毒蜘蛛咬伤后致死。他们被迫去寻找Lecorpus博士（一位定居在当地村庄中的美国医生）以寻求帮助。但是他们很快发现其实这是一个圈套，他们已经成为了献给蜘蛛的一个恶毒宗教仪式的筵席之一。