Vessel is the story of the passengers of Flight 298, a red-eye on its way from Boston to San Francisco. Midway through the flight the passengers encounter an otherworldly force and are subsequently thrown into a fight for their lives. The story focuses on Danny (an everyday traveler), Emma (a flight attendant), Chloe (an unattended underage passenger) and Jim and Murray (the two pilots).

In the distant future, mankind lives on Mars, in cities that resemble those once found on Earth, protected from the alien atmosphere by dome-like force-fields. When a massive sandstorm breaks through the dome and destroys Mars New York, those in Mars Los Angeles must figure out how to stop the storm before it wipes them out next.