After events involving a home invasion, a house cat, an ancient artifact, and an unpaid electrical bill, martial artist Ryo Sakazaki and his best friend Robert Garcia must fight their way into the Southtown underworld to save Ryo's sister Yuri from the crimelord known as Mr. Big.

Shishio's plan is enacted while Kenshin and Misao help defend the city.

Although she's only sixteen and looks even younger, Misao Makimachi is already a skilled and competent member of the Oniwabanshu ninja clan. That's fortunate for Misao, because her onimitsu talents may be all that keeps her alive when a journey in search of the leader of the clan, Aoshi Shinomori, leads her instead into a face-to-face encounter with an even more dangerous man and a plot to overthrow the Meiji government! Quickly enmeshed in the affairs of the legendary assassin Hitokiri Battosai, now known as Kenshin Himura, wielder of the reverse-blade sword, Misao finds herself pulled into the middle of a deadly intrigue against Makoto Shishio, who is orchestrating the conquest of all Japan - beginning with Kyoto!