Comic book store owner Stuart Bloom is tasked with restoring reality after he breaks a device built by Sheldon and Leonard, accidentally bringing about a multiverse Armageddon. Stuart is aided in this quest by his girlfriend Denise, geologist friend Bert, and quantum physicist/all-around pain in the ass Barry Kripke.

Herbert Blount aspires to replace the real director of a movie and make it his own by capturing the lead actress and inflicting much horror upon her in his version.

University physicists Leonard and Sheldon know whether to use an integral or a differential to solve the area under a curve. But they don't have a clue about girls. Or dating. Or clothes. Or parties. Or having fun. Or, basically, life. So when a pretty blonde named Penny moves in the apartment across the hall, the guys decide to get an education outside of the classroom. Boys, you have a lot to learn.