On the trail of her missing sister, Charlotte enlists the help of Wayne, an ex-Marine and alcoholic, to infiltrate the Church of One Accord - a community of snake-handlers who risk their lives seeking salvation in the Holy Ghost.

When an April Fool's Day prank turns deadly, Desiree Cartier, her brother Blaine, and five of their friends all become the targets of a twisted kill who begins hunting them down one by one.