Natsumi Yukihira (Ryoko Shinohara) receives secret documents of an organization that controls the country from the shadows. Because of this, Natsumi's ex-husband, Kazuo Sato (Teruyuki Kagawa) pays a terrible price. Natsumi goes back to the Investigation #1 of Tokyo Metropolitan Police Department to take on the organization, but Natsumi becomes involved in a new case. She gets closer to the final enemy.

After detective Natsumi Yukihira brings an end to the police hospital terrorist case, Natsumi is transferred to the Nishimonbetsu Police Station in Hokkaido. Meanwhile, a series of grotesque murders occurs in downtown Tokyo involving nails placed in the body of the victims. The fingerprint of Natsumi's ex-husband, freelancer journalist Kazuo Sato, is found on the the body of a victim and Kazuo is placed on the most wanted list. Soon after, Kazuo finds Natsumi and hands her a USB memory stick. The device contains information on a secret organization within the police department. Kazuo tells Natsumi that the series of murders are warnings and suspects become the next victims. Natsumi is then arrested as a suspect. Tokyo prosecutor Katsuaki Murakami appears at the Nishimonbetsu Police Station to investigate.

相河一辉（高桥一生饰）在大学教授研究动物行为的“动物行为学”，半年前刚开始讲师的生活，但是他太喜欢各种生物，沉迷于研究，甚至不遵守大学的规则，每天都在职场挨批，而且他不太遵守时间，还被牙医吐槽没常识。一辉非常诚实，有时对学生的提问直接回答不知道，让学生困惑，他坚持兴趣，不守固定观念的样子也影响了身边人的价值观。