Divorced salaryman Yoji has just buried his mother in Tokyo. With few meaningful relationships left, he comes to grips with the realization that he has nothing to live for. A chance encounter with Minerva, a Filipina migrant worker who appears to sense his sadness, urges him to see his situation in a new way. A former nightclub entertainer, Minerva now works as a caregiver to provide for her only child in the Philippines. When Yoji discovers the decomposing corpse of his neighbor, an old man whose name he does not know, the death is ruled a kodokushi, or the lonely death. Unwilling to meet the same fate, Yoji throws caution to the wind to follow Minerva to Manila, the capital city of the Philippines.

In a Japan of the near future, the government program Plan 75 encourages senior citizens to be voluntarily euthanized to remedy a super-aged society. An elderly woman whose means of survival are vanishing, a pragmatic Plan 75 salesman, and a young Filipino laborer face choices of life and death.