Spartacus, determined to bring down the Roman Republic, now leads a rebellion swelled by thousands of freed slaves. Roman leader Gaius Claudius Glaber has died, and former rivals Naevia, Crixus, Gannicus and Agron become rebel generals, joining Spartacus in the war against the empire. The Roman Senate turns to a ruthless politician and soldier, Marcus Crassus, to put down the slaves. Crassus takes on a young rising star - Julius Caesar - as an ally.

新伦敦市民伯纳德·马克思（哈里·劳埃德 Harry Lloyd 饰）和列宁娜·克朗（杰西卡·布朗·芬德利 Jessica Brown Findlay 饰）只知道严格的社会秩序，和一种叫做唆麻的完美药物，服用这种药物是一种即时满足并无处不在的性文化。然而为了探索超越社会限制的生活，二人开始了他们在野蛮之地的假期，却卷入了一场可怕的暴乱。伯纳德和列宁娜被野蛮人约翰（阿尔登·埃伦瑞奇 Alden Ehrenreich 饰）救了出来，约翰和他们一起逃回了新伦敦。