While hosting a masked orgy, socialite Scarlet is murdered by an unknown killer. Hired to investigate the case is put upon private dick Dexter Sleuth, who immediately takes to interviewing the soiree’s various guests.

Chauvinistic businessman Leo Blockman picks up a woman who shoots him, causing him to fall into a river and inexplicably emerge as a woman. Renaming herself Cleo Clock, her female personality gradually begins to take over, and she's forced to navigate a sexist world while attempting to find a way to transform back into a man.