A successful physician and devoted family man, John Dolittle seems to have the world by the tail, until a long suppressed talent he possessed as a child, the ability to communicate with animals is suddenly reawakened with a vengeance! Now every creature within squawking distance wants the good doctor's advice, unleashing an outrageous chain of events that turns his world upside down!

A group of beavers ask Dr. Dolittle to save their habitat from loggers. The only hope is to get the forest preserved because it's the home of a protected bear, but there's a problem: the bear's the only bear in the forest, so she can't reproduce. Undaunted, Dolittle persuades a circus bear to help out, but he has to teach him not just the ways of the wild, but the wiles of lady bears too.

Peter Klaven is a successful real estate agent who, upon getting engaged to the woman of his dreams, Zooey, discovers, to his dismay and chagrin, that he has no male friend close enough to serve as his Best Man. Peter immediately sets out to rectify the situation, embarking on a series of bizarre and awkward "man-dates."