A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.

Nineteen year old pioneer woman Marty has recently married. She goes west with her husband Clem, hoping to start a new life. But Clem unexpectedly dies, and Marty finds herself alone, two months pregnant. Widower Clark offers her a marriage of convenience: she needs food and money, and he needs someone to take care of his daughter Missie. She accepts his proposal as a temporary solution.