Twice a month, Mrs. Bixby travels to Baltimore to visit an elderly aunt, her only living relative. Or so she tells her dentist husband. In fact, she visits the Colonel, her rich lover. Before returning home, he gives her a gift of a fur coat - along with a letter saying that they won't be seeing other any more. Mrs. Bixby decides to pawn the coat but her elaborate scheme to explain the coat to her husband doesn't quite go as planned.

Dan Evans, a small time farmer, is hired to escort Ben Wade, a dangerous outlaw, to Yuma. As Evans and Wade wait for the 3:10 train to Yuma, Wade's gang is racing to free him.