魔尊凤潇潇遭受青云境修士围攻而身受重伤，不得已元神出窍引开追兵。当其元神归来之时发现自己的肉身被札青师李子慕烧毁，还带走了她的本命法宝凤鸣剑。凤潇潇的元神不得已进入青楼女子素素体内，为了恢复法力和拿回凤鸣剑不得已以素素的身份接近李子慕。而李子慕也发现当他和素素身体接触时，他体内的补天石封印产生异动，双方相互试探、调查，于是展开了一段浪漫逗趣的拉扯互动。随着剧情的发展，关于补天石的长生之迷也逐渐展开，杀父之仇、男女之情、苍生之义，也让凤潇潇、李子慕二人爱恨交织相爱相杀。青云境大弟子王正轩修炼禁术肆意夺舍他人身体法力，危害人间，李子慕终为爱打破曾经发下的誓言，勇敢地站在凤潇潇身后，凤潇潇也为爱放下长生之路，联手打败王正轩，守护一方安宁。

In 1916, Chu Shaohua marries Chen Dashun, the eldest son of the Chen family’s pharmacy, to save her brother. With integrity and sharp business skills, she earns the respect of Chen’s father and becomes the manager. After the sudden deaths of Chen’s father and Dashun, the pharmacy passes to Chen Ershun, who squanders the family fortune, driving it to ruin. Through hardship, Chu Shaohua establishes Huashun Pharmacy to support the family. Just as she plans to start a new life with her first love, Xia Chu, Chen Ershun and his mother block her path. When bandits raid the Chen household, Chu loses her daughter and, devastated, leaves for Shanghai. There, her outstanding performance at Yongxin Department Store draws the attention of business talent Wen Zhiqiu, who invites her to co-found a new venture. Step by step, she rises to become a bold and trustworthy woman entrepreneur.