Twelve-year-old Simone feels painfully disconnected from the world after witnessing the brutal death of her mother. Simone, a solitary multimedia artist in her twenties, is struggling to control her crushing panic attacks and keep her day job in an underground parking lot. And Simone, a sixty-year-old physicist, is giving a conference on the nature of time. The three Simones' lives are intertwined in a labyrinthine meta-world where timeframes overlap, characters multiply, and storylines repeat and expand. But, for all its shuttling forward and back through time, ENDORPHINE remains grounded in the Simones' inner lives — it's an artistic examination of scientific phenomena that also poignantly explores how people deal with trauma.

A well-respected plastic surgeon dedicated to helping patients with severe burns questions his career, his family…his perfect life and ultimately, his sanity when an encounter with a disgruntled patient triggers a psychological spiral no one can control.

Despite the fact that he is completely unrepentant about his crimes, when Regis Savoie's son asks to visit him, prison authorities grant permission for the boy to come. The thief and murderer (Gildor Roy) takes advantage of the moment of his son's arrival to steal a gun and take flight. He settles some old scores, gets together with his girlfriend, and heads for the hills, pursued by a detective who is not to be swayed in his efforts to follow and recapture him.