Meg, a music manager, travels from New York to London to manage a boy band, Five Together, and find them a Christmas number one to bolster their flagging career. She finds a song on the internet posted by an ailing thirteen-year-old girl, Nina, and tries to obtain permission to have the song re-recorded by Five Together, but she discovers she has competition from the songwriter, Nina’s uncle Blake. What follows is a romantic comedy about two worlds colliding – with a young woman at the centre who desperately wants her uncle to find love and for his song to hit the number one spot by Christmas Day.

第一幕

這是三百年後的事。世界由環球軟件統轄，並禁止了演奏樂器的權利。("Innuendo")圖晝館員波普因偷看禁書而被捕，上面有一預言：在一顆超新星引領下，它將會被發現並把人類從世界拯救出來。畢業典禮，("Radio Ga Ga")男生伽利略嚮往自由的生活，("I Want to Break Free")和女生史卡拉姆琪一起被警察卡索基拘捕。環球軟件公司總裁出場，("Killer Queen") 她千方百計阻止最後一件樂器被人們發現。("Play the Game")在牢獄中史卡拉姆琪和伽利略漸漸了解對方，("Under Pressure")遂成朋友，更順利逃出。

另一邊廂總裁和卡索基則繼續搜尋傳說中的樂器。("A Kind of Magic")地下組織波希米亞人是一群想尋找音樂的人，("I Want It All")當伽利略和史卡拉姆琪逃出後奧絲和阿域把他們帶他們到總部。("Headalong")他們認為伽利略會是那個超新星，("No One But You [only the good die young]")可卻苦無良策找到甚麼為之搖滾。("Ogre Battle")然而警察們卻追蹤而至把所有人拘捕，可主角二人卻趁亂走了。

第二幕

社會上的人繼續枯燥無味地生活，("One Vision")伽利略和史卡拉姆琪成功破解追蹤器，一夜浪漫。("Who Wants to Live Forever")卡索基盤問波希米亞人不得要領，("Flash")遂下令把所有人洗腦。("The Seven Seas of Rhye")總裁得知波希米亞人下場深感快慰，("Don't Stop Me Now")但在知道有二人在逃便下令全力緝捕，更把卡索基洗腦以作懲罰。("Another One Bites the Dust")伽利略和史卡拉姆琪繼續找方法來救人，("Hammer to Fall")他們找到還沒完全洗腦的波普，他很想記起以前的事。("These are the Days of Our Lives")

終於伽利略和史卡拉姆琪找到眾人，波普和他的電單車幫助二人去找那件樂器。眾人來到那個地方，卻找不到甚麼樂器。為了秉持波希米亞精神，在沒有樂器之下也要有音樂，伽利略先來清唱，漸漸聽到有一樂器在奏著　－　一部電結他。("We Will Rock You")終於全世界也被此音樂感動，總裁的計劃全盤失敗了。("We are the Champions")眾波希米亞人也找到了自己失去的東西。("Bohemian Rhapsody")