自小在孤儿院长大的华一龙，为了替孤儿院的孩子治病，考入全国顶尖的医学院，并在这里结识了魔鬼导师段添城、跆拳道女孩栗小草、“学霸”楚枫、农村来的郝开心和“富二代”权美秀。几个性格各异的医学生朝夕相对，在实现理想的路途中并肩前行。在与伙伴的相处和与老师的交锋中，华一龙获得了伙伴们珍贵的友谊，与栗小草的恋情也逐渐发展，和段添城从相互对抗到相互认同，并且在伙伴们的帮助下，为段添城完成了脑瘤手术，最终从一个对医学一无所知的倔强少年成长为一名合格的医学生。

Four police officers open up a lobster restaurant as a cover in order to catch a notorious drug dealer, only to find their secret recipe is more popular than they expect. When they get caught up in their new business venture, they find a bigger conspiracy at work.