Yak arrives at the Gilmore ranch where rustling has occurred. Gilmore blames a wild horse when it is actually his foreman Mays. After Yak catches and tames the wild horse, Mays gets Yak out of the way by having him arrested for murder. Mays and his men can now make one last raid.

Criminologist Carter Holmes travels the globe trying to recover and keep safe the 9 daggers which will unlock a secret vault containing the Devil's Trademark, an ancient relic with massive power. The relic was uncovered from an Egyptian temple and relocated to the vault by scientist Dr. Stanhope. Stanhope is murdered as various nefarious parties compete to get the daggers first - sometimes working together, sometimes helping Carter.Stanhope's daughter Ruth (also Carter's girlfriend) is constantly being kidnapped as a bargaining chip, as well for sex slavery and human sacrifice, by Devil worshippers,a Turkish sheik, the masked Monsieur X, a few lesser criminals, and the supernatural Asian Dr. Wang Foo who plans on world dominion.

As described in a film magazine, Bess Thurston (Gerber), whose no-account brother Jack (Pegg) is unable to support her, obtains employment in a dance hall. This shatters the illusions of Cheyenne Harry (Carey), who has fallen in love with her. When he rescues her from the advances of Beau Ross (Harris), Cheyenne's confidence in her is restored. Her brother then aids Beau in an attempted robbery and Harry allows them to escape. Beau takes Bess with him into the desert. Harry follows and a duel ensues in which they are both wounded. Bess rides the only horse left out of the desert, while Beau and Harry struggle along on foot. A sandstorm results in the death of Beau, but Harry lives to find happiness with Bess.