George Lollar takes his family on vacation with "Club Sand", a shoddy and untrustworthy company. On their tropical island, they find soldiers everywhere, an unhelpful staff, inhospitable accomodation and undesirable holiday makers, but everyone except for George manages to have fun in the sun.

Lewis and his nerdy friends attend Booger's wedding to the daughter of a rich politician, but nerd-haters in the family do everything possible to prevent the wedding going ahead. Meanwhile, Lewis awaits with eagerness the birth of his unborn foetal child...

The nerds are now in control of the university, as a result of Lewis Skolnick and the rest's actions in the two previous movies. A new generation of sportsmen arrive, however, determined on winning the school back. The principle, himself an ex-nerd fighter, helps them, and the nerds return to suppression. Harold Skolnick needs help from his uncle Lewis, the hero of the first two movies. Lewis, however, are not too proud of his nerd past, and won't reveal any of it, much less help his nephew. However, his wife makes him change his mind, and with help from his friends from the first two movies, they start the fight to win the school back, using classic nerd tricks.

It's recruiting time and despite being short and scrawny, Johnny Walker is America's hottest young football prospect. His dilemma: should he take one of the many offers from college talent scouts or should he attend the local state college with his girlfriend and give up his football career?