The story of Franklin Roosevelt's bout with polio at age 40 in 1921 and how his family (and especially his wife Eleanor) cope with his illness. From being stricken while vacationing at Campobello to his triumphant nominating speech for Al Smith's presidency in 1924, the story follows the various influences on his life and his determination to recover.

Eager to land a journalistic position, Adam White goes to work as an advice-giving newspaper columnist. His editor, Shrike, takes pleasure in browbeating his alcoholic wife Florence for her past adultery, and assigning his employees journalistic jobs for which they have little aptitude or interest. Shrike goads Adam into meeting one of his correspondents, Fay Doyle, a teary, self-pitying woman who makes a play for him. Adam is torn between his loyalty to the newspaper and his girl Justy.