In the sixteenth century, Francis Barnard travels to Spain to clarify the strange circumstances of his sister's death after she had married the son of a cruel Spanish Inquisitor.

Convinced that his family’s blood is tainted by generations of evil, Roderick Usher is hell-bent on destroying his sister Madeline’s wedding to prevent the cursed Usher bloodline from extending any further. When her fiancé, Philip Winthrop, arrives at the crumbling family estate to claim his bride, Roderick goes to ruthless lengths to keep them apart.