Jackie Brown is a flight attendant who gets caught in the middle of smuggling cash into the country for her gunrunner boss. When the cops try to use Jackie to get to her boss, she hatches a plan — with help from a bail bondsman — to keep the money for herself.

After her younger sister gets involved in drugs and is severely injured by contaminated heroin, a nurse sets out on a mission of vengeance and vigilante justice, killing drug dealers, pimps, and mobsters who cross her path.