《毒枭》在经过三季于哥伦比亚的反毒战争后将告一段落。Netflix将原来的第四季独立出来作为衍生剧《毒枭：墨西哥篇》（Narcos: Mexico）。
本作将聚焦于反毒战争的起源 – 墨西哥的瓜达拉哈拉贩毒集团，时间也将移前至80年代，讲述冷静﹑大胆﹑头脑清晰﹑忠于 亲友的Felix Gallardo（Diego Luna饰）如何把散乱的贩毒者统一起来，成为被称为「Godfather」的大毒枭。
而缉毒局探员Kiki Camarena（Michael Pena饰）带着妻儿从加州搬到瓜达拉哈拉，但他没意料到此反毒战的危险程度，并引发了惨剧。在《毒枭》第一季中曾提到，Kiki被贩毒集团抓获后，死前曾被剥了两腿的皮﹑对着手脚开枪﹑用电钻钻头等。不过他的死也令缉毒局开始对毒枭穷追猛打。

Despondent over a painful estrangement from his daughter, trainer Frankie Dunn isn't prepared for boxer Maggie Fitzgerald to enter his life. But Maggie's determined to go pro and to convince Dunn and his cohort to help her.

In the affluent, gated community of Camelot Gardens, bored wives indiscriminately sleep around while their unwitting husbands try desperately to climb the social ladder. Trent, a 21-year-old outsider who mows the neighborhood lawns, quietly observes the infidelities and hypocrisies of this overly privileged society. When Devon, a 10-year-old daughter from one family, forges a friendship with Trent, things suddenly get very complicated.

Determined to prove herself, Officer Judy Hopps, the first bunny on Zootopia's police force, jumps at the chance to crack her first case - even if it means partnering with scam-artist fox Nick Wilde to solve the mystery.

Vincent is an all-too-human man who dares to defy a system obsessed with genetic perfection. He is an "In-Valid" who assumes the identity of a member of the genetic elite to pursue his goal of traveling into space with the Gattaca Aerospace Corporation.

An agent falls for a drug baron's sister while investigating possible police collaboration with a terrorist cell at the border of Ceuta and Morocco.

With his eye on a lovely aristocrat, a gifted illusionist named Eisenheim uses his powers to win her away from her betrothed, a crown prince. But Eisenheim's scheme creates tumult within the monarchy and ignites the suspicion of a dogged inspector.

该剧讲述了一位“法律上已宣布死亡”的前CIA特工，受雇于一位神秘的亿万富翁，打自主正义牌，用私人力量来打击犯罪保护人民。
卡维泽所饰演的角色名叫Reese，他在秘密行动中所受的特殊培训得到了爱默生的角色Finch的注意。Finch是一名软件天才，他发明了一种可以使用模式识别即将行使暴力犯罪族群的程式。用这种国家最先进的监视技术，这两人游离于法律之外，用Reese娴熟的特工能力以及Finch无限的财富，揭开那神秘的犯罪嫌疑人，并在犯罪发生之前制止它。
Reese的行动受到了NYPD-纽约警局的关注，包括凶杀科侦探Carter，以及Fusco，一名Reese曾经利用过的警丵察。而Reese和Finch发现，在这个私人隐私被肆意暴露，每个人都被政府“老大哥”监视的时代，只要正确地利用信息、在正确的时间、发现正确的人，便可以制止犯罪，改变一切。
CBS已续订第三季

Mr. Finch (Michael Emerson), a mysterious billionaire, developed a computer program for the government that predicts terrorist threats to the US. It was designed as a means to prevent another 9/11-type disaster, but Finch discovered that it was also predicting many "irrelevant" (non-terrorist) crimes. The non-terrorist data is dumped to a separate database and deleted each night. Finch realized that a great many domestic crimes could also be prevented if that data could be used. Finch built a backdoor into the machine that allows him to retrieve a list of Social Security numbers of people who will be involved in those crimes in order of occurrence. Unable to investigate the data on his own, Finch hires John Reese (Jim Caviezel), a former Green Beret and CIA field officer who is presumed dead, to help stop the crimes from taking place. The world thinks that Finch, like Reese, is dead. Finch made the choice of only transmitting the Social Security Numbers of the persons of interest so that if the backdoor is discovered, the government would have no clue as to what the numbers mean or that Finch is still alive.

The Sensates face growing dangers and harrowing personal battles as they begin to unravel the truth about the shadowy forces out to destroy them.

大学辍学生迈克（帕特里克·J·亚当斯 Patrick J. Adams 饰），在一次贩毒失败后闯进了一个高材生云集的招聘会，原来这是曼哈顿最著名的律师哈维（盖布瑞·马赫特 Gabriel Macht 饰）在招聘律师助手。在众多哈佛高材生中，哈维看中了聪明机警、记忆力发达的迈克。尽管他发现迈克非但不是哈佛法学院学生，而且他还有吸大麻的恶习，但他还是决定瞒着上司，招迈克做助手。于是，哈维和迈克组成了一支“金装组合”，在律师事务所中成为常胜搭档。
迈克虽然有着天才般的头脑，但在法律上他还是一名新手，加入事务所之后遇到了各种难题，而冷面律师哈维并没有对他处处提点，因此迈克总是四处碰壁，而哈维的对手路易更是处处刁难他……