散歩中のニャンコ先生が迷子の双子兄妹に出会うことからドラマが展開していく。

第5期Blu-ray/DVDに収録の新作エピソード。それぞれ前編・後編と、連続したエピソードとなっている。
脚本 吉永亜矢
絵コンテ 寺東克己
演出 小林孝志
作画監督 川添政和、伊藤秀樹、宗崎暢芳、青野厚司、合田真さ美
総作画監督 伊藤秀樹

Blessed with eyes that are able to perceive the otherwise invisible youkai, Takashi Natsume hides his ability from his newfound family and friends to protect everyone's peaceful daily life.

Meanwhile, the exorcist clan Matoba still wishes for Natsume to join their ranks due to his overwhelming gift. However, Natsume firmly rejects the clan's invitation since not all exorcists are as reasonable as his friend Shuuichi Natori, and many improperly and indiscriminately seal away every youkai in their way. Unsatisfied with Natsume's answer, Seiji Matoba blackmails Natsume into attending a grand gathering of powerful exorcist families. Natsume soon finds himself in the company of dangerous people and youkai alike. But even then, he continues to defy the exorcists' hard-handed methods and believes that peace between both worlds is possible.

4期にわたり放映されたアニメ『夏目友人帳』の完全新作OVA。妖怪を見ることができる夏目貴志が、自称用心棒の妖怪・ニャンコ先生と共に妖怪たちと交流する様を描く。