In the summer of 1983, a 17-year-old Elio spends his days in his family's villa in Italy. One day Oliver, a graduate student, arrives to assist Elio's father, a professor of Greco-Roman culture. Soon, Elio and Oliver discover a summer that will alter their lives forever.

In 1960s Wyoming, two men develop a strong emotional and sexual relationship that endures as a lifelong connection complicating their lives as they get married and start families of their own.

Adèle's life is changed when she meets Emma, a young woman with blue hair, who will allow her to discover desire, to assert herself as a woman and as an adult. In front of others, Adele grows, seeks herself, loses herself, finds herself.

Best friends as children, Mew and Tong run into each other years later as young men and find they have unexpected feelings for each other.