When an IMF mission ends badly, the world is faced with dire consequences. As Ethan Hunt takes it upon himself to fulfill his original briefing, the CIA begin to question his loyalty and his motives. The IMF team find themselves in a race against time, hunted by assassins while trying to prevent a global catastrophe.

In the year 2044, time travel has not yet been invented but in 30 years it will have been. When the mob wants to get rid of someone, they will send their target into the past where a looper, a hired gun, like Joe is waiting to mop up. Joe is getting rich and life is good until the day the mob decides to close the loop, sending back Joe's future self for assassination.