Whether on or above Earth, hilarity is outrageously universal in TV's most popular comedy featuring four forward-thinking but socially backward geniuses. Fun discoveries multiply: Leonard learns jealousy is bad for a relationship (with Penny) but science is good for seduction (of Penny). Howard finds life in the International Space Station life is no escape from terrestrial turmoil between his mom and his new wife Bernadette. Raj meets someone special who may be a good match, if he can keep her from fleeing mid-date. And then there's Sheldon. He learns what not to say after facing harassment charges or competing for tenure at work and how Dungeons & Dragons can be the icebreaker his relationship with Amy needs.

In season five, Penny and Leonard's relationship is relaunched in full "beta test" mode, while Sheldon, Howard, and Raj discover the feminine mystique is something that cannot be easily graphed or calculated. As Sheldon makes begrudging amendments to his "Relationship Agreement" with his "friend-who-happens-to-be-a-girl" Amy Farrah Fowler, Raj contemplates an arranged marriage, and Howard is all-systems-go for both is NASA space launch and wedding to the spirited Bernadette.