Raised a boy in East Berlin, Hedwig undergoes a personal transformation in order to emigrate to the U.S., where she reinvents herself as an 'internationally ignored' but divinely talented rock diva, inhabiting a 'beautiful gender of one'.

In post-9/11 New York City, an eclectic group of citizens find their lives entangled, personally, romantically, and sexually, at Shortbus, an underground Brooklyn salon infamous for its blend of art, music, politics, and carnality.