Actress Myrtle Gordon is a functioning alcoholic who is a few days from the opening night of her latest play, concerning a woman distraught about aging. One night a car kills one of Myrtle's fans who is chasing her limousine in an attempt to get the star's attention. Myrtle internalizes the accident and goes on a spiritual quest, but fails to finds the answers she is after. As opening night inches closer and closer, fragile Myrtle must find a way to make the show go on.

Mabel Longhetti, desperate and lonely, is married to a Los Angeles municipal construction worker, Nick. Increasingly unstable, especially in the company of others, she craves happiness, but her extremely volatile behavior convinces Nick that she poses a danger to their family and decides to commit her to an institution for six months. Alone with a trio of kids to raise on his own, he awaits her return, which holds more than a few surprises.