Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.

前传故事将通过主人公奈维尔博士的视角，展现人造病毒引发的瘟疫开始洗劫人类后的纽约城最后几天内的情景。
《我是传奇》的制片人Akiva Goldsman与Overbrook娱乐公司的James Lassiter还有威尔·史密斯将担任制片工作。