Ashitaka, a prince of the disappearing Emishi people, is cursed by a demonized boar god and must journey to the west to find a cure. Along the way, he encounters San, a young human woman fighting to protect the forest, and Lady Eboshi, who is trying to destroy it. Ashitaka must find a way to bring balance to this conflict.

After her werewolf lover unexpectedly dies in an accident, a woman must find a way to raise the son and daughter that she had with him. However, their inheritance of their father's traits prove to be a challenge for her.