After a lightning bolt zaps a robot named Number 5, the lovable machine starts to think he's human and escapes the lab. Hot on his trail is his designer, Newton, who hopes to get to Number 5 before the military does. In the meantime, a spunky animal lover mistakes the robot for an alien and takes him in, teaching her new guest about life on Earth.

In the 22nd century, a paraplegic Marine is dispatched to the moon Pandora on a unique mission, but becomes torn between following orders and protecting an alien civilization.

Robert Neville is a scientist who was unable to stop the spread of the terrible virus that was incurable and man-made. Immune, Neville is now the last human survivor in what is left of New York City and perhaps the world. For three years, Neville has faithfully sent out daily radio messages, desperate to find any other survivors who might be out there. But he is not alone.