After kidnapping a father and his two kids, the Gecko brothers head south to a seedy Mexican bar to hide out in safety, unaware of its notorious vampire clientele.

Two doctors find their graveyard shift inundated with townspeople ravaged by sores. Among the wounded is Cherry Darling, a dancer whose leg was ripped from her body. As the invalids quickly become enraged aggressors, Cherry and her ex-boyfriend El Wray lead a team of accidental warriors into the night.