The series takes viewers to the epicenter of America's struggle with opioid addiction, from the boardrooms of Purdue Pharma, to a distressed Virginia mining community, to the hallways of the DEA.

Offred must navigate between Commanders, their cruel Wives, domestic Marthas, and her fellow Handmaids – where anyone could be a spy for Gilead – with one goal: to survive and find the daughter who was taken from her.