During a cattle drive, Don McGow leaves the herd in charge of his younger brother and rides off. When the herd is reported stolen he blames himself and goes in search of the thieves.

Shortly after his return from India, a special agent of the British secret service falls victim to an insidious poisoning in London. Scotland Yard gets involved. But too late: valuable information has fallen into the hands of an international criminal gang...

In the Olden Tymes, Count Regula is drawn and quartered for killing twelve virgins in his dungeon torture chamber. Thirty-five years later, he comes back to seek revenge on the daughter of his intended thirteenth victim and the son of his prosecutor in order to attain immortal life.

Rollins' gang wants to grab land by inciting the settlers in a war against the Indians but Winnetou and Old Shatterhand try to keep the peace, until Rollins frames Winnetou up for the murder of Jicarilla Chief's son.