Four best friends fart through their last years of college, hanging out, drinking and eating lots of sandwiches. Using break-ups and re-occurring scholastic failures to impose a quarter-life crisis, they take turns postponing responsibility, avoiding accountability, and looking for someone or something to substantiate their lives, all the while hedging their bets and mastering the art of treading water and getting away with it.

When Jim - a disenchanted yet highly popular college professor - learns of his fathers death, he must track down his deadbeat brother Dave and deliver him to the funeral. Upon arrival, they both learn that they've each inherited one half of the family's vacation home in Branson, Missouri, and in order to sell the house - which they both badly need the money from - they'll need to travel down to Branson, and the ensuing trip both fixes their house, as well as their relationship.