It is a time of chaos. Earth is no longer what it used to be. It has been infested with a bug like species called the Blue. Yuji Kaido, who has a mysterious disease, is put into suspended animation until a cure is found. When he wakes up Yuji learns that its been more than 20 years since he was put into suspended animation, and the world is now controled by these creatures. He joins a group of soldiers equipped with powerful mechas to fight against the Blue for hope of a better future.

在阳光明媚的日子里，纽约街头宁静的一隅，梅可和乔（渡边明乃 配音）正在讨论该给即将过生日的夏丽送什么样礼物的问题。这时一位老太太前来求助，希望她们帮忙拯救困在树上的猫。两人顺利救下小猫，并刚好得到钱买到礼物。她们来到警察局，找到当初好心收养了夏丽的黑人警察萨姆，却得知不久前纽约市出现了一个无差别连环杀人凶手，这个死人一样狰狞的家伙伤害了数条人命，其中包括天真无邪的夏丽。面对仍徘徊在死亡线上的女孩，乔和梅可义愤填膺，萨姆似乎知晓对方的真实身份，但是因为有政府不可告人的黑幕存在，他空有悲愤却掣手掣脚。 未过多久，连梅可也宣告失踪……

Less than a year after Geist activated the Death Force, which decimated most of Jerra's population, he has kept himself busy by dismantling the Death Force machines one by one. Most of the remaining human population have fled to a remote haven run by a warlord named Krauser. Krauser is another MDS unit, MD-01, who has a technology that hides his mobile fortress from the Death Force.

Geist (the main character) is MD-02, a Most Dangerous Soldier, genetically engineered to function as a killing machine, but every one of the MDS units went homicidally insane. As a result Geist was placed in suspended animation in a stasis pod orbiting the planet Jerra until it crashed several years later, awakening him and bringing him into another war on the planet.

Biohazard 4D-Executer is a Japanese computer-animated 3D horror film based on the Resident Evil series of survival horror video games. It was created by Capcom in cooperation with Visual Science Laboratory, and distributed by Digital Amuse. Biohazard 4D-Executer was directed by Koichi Ohata, and written by Daisuke Okamoto, who was supervised by the game series developers. A limited release, the 20-minute film has been an attraction in Japanese theme parks since November 2000, and can be seen in movie theaters and smaller booths. The story centers on the mission of a military squad sent to the zombie-infested Raccoon City to locate the whereabouts of Dr. Cameron, a female scientist conducting research on a new type of virus.