This is the first of the Sherlock Holmes' stories by the famous English author. Sir Arthur Conan Doyle. Sherlock Holmes and his friend, Dr. Watson, receives an invitation from Mr. Gregson, of Scotland Yard, to assist in unraveling a murder mystery. Holmes makes a careful study of the case and as a result of his ingenious deductions rounds up the murderer, one Jefferson Hope, a cabman. The man confesses his guilt and tells his life story and of the vengeance of the many wrongs he has suffered at the hands of the dead man in the years gone by. Before the case comes to trial the prisoner dies from heart failure. This is another victory for Holmes and his wonderful deductive methods, as the officers of Scotland Yard had all but fastened the guilt upon another and an innocent person.

Bob Evans, a telegraph operator, together with a group of soldiers gets ambushed by Sioux Indians. Wounded, he climbs into a telegraph pole and asks through the telegraph wires for help from the fort. Bob's fiancée Edith comes along with the soldiers. The soldiers find only dead bodies and decide to chase the Indians. Edith stays behind to search for Bob. She finds him and together they return to the fort. The Sioux then attack the fort, but when the situation seems hopeless, the army returns and the Indians are expelled.

Easterner Robert Wagner has been lured West by the Government's announcement of new land grants. As he prepares for the approaching land rush he make the acquaintance of Westerner Jim Henderson and his wild daughter, Tex. Tex is a true daughter of the frontier unhampered by conventions or skirts and while she finds herself smitten with Wagner, he however is hampered by his New England sensibilities and can't abide a woman that behaves as Tex does. It takes a truly grim turn of events before Tex can prove herself to this reserved New Englander.

In the film, Cunard plays a jewel thief pursuing the same wealthy marks as another thief, played by Francis Ford.

The U.S. Army and the Indians sign a peace treaty. However, a group of surveyors trespass on the Indians' land and violate the treaty. The army refuses to listen to the Indians' complaints, and the surveyors are killed by the Indians. A vicious Indian war ensues, culminating in an Indian attack on an army fort.

A movie serial directed by Francis Ford.