The story takes place in a future where the human race has expanded and inhabits a multitude of planets in the universe with fantastic technology. Unsurprisingly, crime has grown alongside technology, and thus the GOTT, Galactic Organization of Trade and Tariffs, is formed as a sort of universal police force. Within this organization, there is a special (and secret) branch known as the ES Force (ES standing for "Encounter of Shadow-work"), consisting of twelve young people that possess amazing superpowers. Each ES member operates with another as a team, and the series' focus is a team of two low-level members, Éclair and Lumière. As the series progresses, they start to see the darker side of GOTT and its secrets.

In a future, decimated Earth after the discovery of a mysterious, alien spacecraft dubbed "Orphan". A group of researchers scour the planet for Orphan's disc plates using mecha called "Antibodies" in order to revive the craft, an event that would result in the utter destruction of all lifeforms on Earth. The protagonists Yu Isami and Hime Utsumiya must utilize a special Antibody called "Brain Powerd" to counter the Orphan plans and save humanity.