Inside the high-stakes emergency department of Chicago’s top hospital, a team of doctors and nurses faces intense medical cases while navigating complex emotions and ethical dilemmas. The adrenaline never stops — and neither does the pressure.

McNulty's on harbor patrol. Daniels is in the police-archives dungeon. Prez is chafing in the suburbs. Greggs has a desk job. The detail may be on ice, but corruption marches on . . . and a horrific discovery is about to turn the Baltimore shipping port inside out. Setting up in the wake of the first season's joint homicide/narcotics detail that exposed a major drug operation — and left its members stigmatized and reassigned — the second season expands to include not only familiar drug dealers, but a group of longshoremen and organized crime members who are caught up in a major homicide case.