Perfume creator Satin Chau is about to reveal her new designer scent, 'Puppy,' when she is cruelly struck down by a rare condition called anosmia, which robs her of her sense of smell and could even kill her. With time fast running out, she begins a frantic search for the only people who can provide the tissue-donations she desperately needs: her long-lost sisters, Corduroy and Velour.

Charlie Brandis leads a quiet and uneventful life as a wallflower. His parents trust him, his friends like him, girls are indifferent toward him. Then there's the girl he's watched from afar, Annie Briggs, who doesn't even know he exists. Until today. For today, the powers of fate conspire against him when jock friend Gary decides to throw a party at Charlie's house because the Brandis parents are away; a party specifically orchestrated to do one thing, put Charlie and Annie (who is unaware of this plan) together. The wrench comes in the form of Gary's older sister Margot, a girl who Charlie has also loved from afar, and who might be interested in him as well. The question is, when will Charlie stop doing things because other people want him to and take stock in his own situation.

80年代红极一时的家庭喜剧影集「欢乐家庭」回来了！相信许多喜爱这个影集的观众一定还记得席维尔一家人，如今原班人马再次重现萤光幕，让大家看见他们的成长。 七年后，Seaver一家住在华盛顿的新房子里。Jason，Maggie和Chrissy住在一所大房子里，Ben以在因特网上卖东西为工作，Carol在最高法院工作，Mike与他的妻子Kate生活得多姿多彩。他们收养了三个不同种族的孩子，这些孩子都喜欢把Mike和Kate当作父母。华盛顿进行了一次政俯选举，Maggie发现她的候选人用了肮脏的手段获胜。很快地她就被解雇了，但是马上她决定与他斗争到底。她的对手找来一个叫Craig的人来帮他，而Carol则帮助Maggie。Craig和Carol很快的好上了并且开始秘密的约会。 Chrissy养成了拍摄她所见到的各种东西的习惯，以此来作为学校作业。Ben犯了一个错误，一个叔叔和迈克的孩子们全都被卷入了车祸，这差点让Maggie失去作议员的资格，但结果却以外的让Maggie赢得了更多的选票。Carol发觉Craig参与了对外界大肆宣传这起小事故后就与他分了手，但是为了Craig的儿子，他们很快重修旧好。Ben去城郊为Maggie拉选票，与一位美籍非洲姑娘相恋。Mike发现了Carol与Craig秘密的幽会，他决定给Craig一个小小的警告。Maggie以压倒性的胜利击败了竞争对手，成为华盛顿的新议员。 Chrissy把Maggie的胜利记录了下来，并因此她的学校作业得了个A+。Ben与他遇到的姑娘确立了关系，而Caig听从了Mike的建议向Carol求了婚，最终他们结为了夫妻！

Jason和Maggie在《成长的烦恼2：希瓦一家的归来》中准备开始他们生活新的一章。他们决定卖掉他们的房子，并准备去旅行来度过他们的退休生活（Maggie一直渴望去Tuscany的别墅，而一向节省的Jason希望在一辆 Winnebago房车里去环游美国）。但是一切都是说起来容易做起来难。Mike和已经怀孕的Carol为了各自的事情一起合伙阻止这次父母的离开；此时，小儿子Ben（一个房地产经纪人），需要靠卖掉他父母这幢房子的生意来取悦他的老板。同时，Chrissie，一个充满渴望的歌手，只想能够从父母的严密管束下脱离出来而开启她的摇滚明星的职业生涯。现在故事刚刚开始............