Every neighborhood has a Karen, and Amityville is no exception. When stealing a cursed bottle of wine from a struggling local brewery, Karen soon finds that the price to pay is far more dangerous than your average hangover. Everyone in her path becomes prey, and not even a manager can be called in to stop her.

The last Spring Break of high school is fast approaching and Dylan, a senior from Bend, Oregon, has just been dumped by his longtime girlfriend. His childhood friends Billy and Maxi want to help out but they haven't been as close while Dylan has been in a relationship. So Billy and Maxi kidnap him in a stolen RV and head to the epic Spring Break destination of Lake Havasu City, Arizona.