While returning to Los Angeles in a trailer through the desert, the driver Neil convinces his friends Tara, Harmony, Loopz, Michelle, Lee and Cashie to take a detour to an isolated mine where it could have a plantation of peyote. The owner of a gas station advises the group to not go to the place, but the stubborn Neil does not pay attention to his words. While driving in a secondary road, Neil sees a girl and wrecks the car in a rock. He decides to walk back to the gas station to call a tow truck, while Michelle and Lee climb a hill trying to get signal to their cell phones. Sooner the teenagers find that they are under siege of a group of sadistic deformed cannibals and they have to fight to survive.

Two years after the Martian invasion, George Herbert's worst fears are realized: The Aliens have returned. As a second wave of Martian walkers lay waste to what's left of Earth, an alliance of military forces prepares a daring attack on the Red Planet itself. Once again, the future of mankind hangs in the balance.