When Ross is diagnosed with terminal brain cancer and given six weeks to live, his newly engaged older brother Seth offers to spend his $50,000 wedding fund on a final trip of a lifetime. Their plans are complicated when Ross invites a call girl to join the group and Seth’s uptight fiancée insists on tagging along. This raucous road trip comedy features hip-hop star Asher Roth.

Two friends spend all their free time building flame-throwers and weapons of mass destruction in hopes that a global apocalypse will occur and clear the runway for their imaginary gang "Mother Medusa".