一个检察官的女儿罹患重病，需要进行器官移植。为了能找到新鲜的器官替换，检察官前往墨西哥寻访。没想到却在那里发现有很多儿童被杀害，就为了拿他们身上的器官卖钱。检察官一方面想救孩子们，另一方面却又担心女儿的病情，自己陷入左右为难之中。

凯修到缅因州的歌尔斯岛度假，这个远离尘嚣的小岛上居民不多，而凯修的到来显然不被岛民所接受，除了小学生物课女教师妮尔肯帮他外，其余人都很排拆凯修。另外，自从凯修来到岛上之后便不断有人神秘死亡，岛上警长以为是意外，但身为外科医生的凯修发现受害者的尸体都有被虫咬过的痕迹，于是和妮尔一起着手展开调查，并将虫体送到美国本土的医学院研究，没想到这些骇人听闻的蟑螂竟是来自遥远的非洲稀有品种，它们利用人类的身体作为繁衍的巢穴，而且有强大的破坏力，任何人，畜都不能避免。 由于蟑螂的快速繁衍，没多久歌尔斯岛上已经被成千上万的蟑螂入侵，而且居民们一个个都被蟑螂吃掉，最后只剩下凯修、妮尔等几个人，他们与恐怖的吃人蟑螂展开了大对决！

Treasure hunter Ben "Finn" Finnegan has sunk his marriage to Tess and his trusty boat in his obsessive quest to find the legendary Queen's Dowry. When he finds a vital clue that may finally pinpoint the treasure's whereabouts, he drags Tess and her boss, billionaire Nigel Honeycutt, along on the hunt. But Finn is not the only one interested in the gold; his former mentor-turned-enemy Moe Fitch, hired by rapper-turned-gangster Bigg Bunny, will stop at nothing to beat him to it.

A scientific expedition sets out for Borneo to seek a flower called the Blood Orchid, which could grant extended life. Meanwhile, they run afoul of snakes and each other.