A trio of young scientists investigate a source of uranium at the base of a sacred mountain, and after running over a dog, find themselves cursed by the locals.

Ayame, a courtesan, attracts the attention of street vendor Kisuke and decides to run away with him to America. Unfortunately, a crazed tattoo artist is obsessed with Ayame's perfect skin as a potential canvas, so he kills Kisuke to keep Ayame in Japan. Later, Ayame is sold to a brothel in Yokohama. Kisuke's ghost possesses her, causing his image to appear tattoo-like on her skin whenever she has sex.