At Hope's Peak Academy, a school full of extraordinarily talented individuals, Nagito Komaeda is an ordinary boy with no special traits or interesting skills to speak of-except for his incredible unluckiness. Just walking to school in the morning leads to a number of unfortunate accidents, which only escalate as the day goes on. Despite this, Komaeda leads a relatively normal life and is satisfied with his modest slice of happiness. But everything changes when a mysterious boy who declares himself the "Destroyer of the World" arrives to shatter this hopeless paradise.

The Future Foundation is in shambles after the Final Killing Game and the revelation of the true culprit. As a desperate plot arises from one of the survivors to rid the world of despair once and for all, the remaining Future Foundation members must band together to stop this atrocity from taking place. Fortunately, they find themselves with help from a group of unlikely allies as they race against the clock to stop their world from being changed. In this finale to the Hope's Peak storyline of the Danganronpa series, the players in this neverending death game begin to understand the true meaning behind despair, hope, and atonement.