A young girl's parents are killed on a tropical island, and the girl is raised and protected by the jungle animals. When she is found, as a grown woman, she is taken back to the United States to claim her inheritance. There are several people, with vested interests, who stand to gain something if she is shown not to be the missing heir.

Gardoni, a down-on-his-luck vaudeville performer, is taken in by a fellow performer, a clown who has a bicycle riding act. Gardoni shows his appreciation by stealing the clown's act and his girlfriend, whom he marries.

Jeff grows up near Basin Street in New Orleans, playing his clarinet with the dock workers. He puts together a band, the Basin Street Hot-Shots, which includes a cornet player, Memphis. They struggle to get their jazz music accepted by the cafe society of the city. Betty Lou joins their band as a singer and gets Louie to show her how to do scat singing. Memphis and Jeff both fall in love with Betty Lou.

Jeanne Eagels plays the bored and restless Leslie Crosbie who turns to another man, Geoffrey Hammond (Herbert Marshall) for attention when neglected by her husband Robert (Reginald Owen). Robert decides to go out for the evening to pick up a new rifle. Leslie's calm vanishes as she awaits an answer to a letter she has written Hammond. He has found a new love - a beautiful unscrupulous native woman Li Ti (Lady Tsei Mei) and has discarded Leslie.