When a powerful new Makamou attacks and defeats Hibiki, Asumu dives into Takeshi’s history and discovers a book that details the ancient Oni and a boy sharing his name. As he reads on, he learns of the tensions between humans and Oni as they struggle to stop the Orochi Makamou, but will he discover the key to defeating the new Orochi in the present?

It has been two years since unsuccessful cartoonist Tsube started to live with Kuniko casually in a small apartment.

第二次世界大战接近尾声，在冈山县日比海岸，赤城大夫（柄本明饰）继承父亲传下的开业医生必须鞠躬尽瘁的家训，终日奔走，四处出诊，却只收取微薄的报酬。他发现许多居民都出现肝肿大的症状，肝炎正在流行扩散。情势不妙，赤城开始全力探索肝炎的病原体，并需要借助显微镜研究肝炎病毒。
被雇来当看护助手的女孩园子（麻生久美子饰），是名从良的卖身女，她默默地爱着这位热心的大夫。在园子、受重伤的荷兰战俘以及其他朋友的协助下，赤城努力救治染病的人们。不久，广岛上空升起了巨大的蘑菇云，隔海而望，那云的形状就如同肿胀的肝脏……

2003 film by Takashi Shimizu