The Powerpuff Girls face their greatest challenge in this 10th anniversary special episode. There exists a Key to the World, which is handed from city to city on an annual basis. Whoever possesses the key rules over the entire world. When the key is delivered to Townsville, every villain in Townsville attempts to retrieve it. When the girls procure it for themselves, they quickly get sucked into a power struggle, fighting the villains and themselves over who gets to rule the world.

Mickey's Lunar New Year feast is placed in jeopardy after a mysterious creature steals the main course.

Genndy Tartakovsky's Primal: Tales of Savagery features a caveman and a dinosaur on the brink of extinction. Bonded by tragedy, this unlikely friendship becomes the only hope of survival.