Mel, a Las Vegas "wise guy", asks his friend Jag to help him with a simple task. Jag goes to the meeting location to meet up with Mel and brings his girlfriend along, but he is attacked and his girlfriend kidnapped. Mel arrives just in time to save Jag from certain death. To help save the girlfriend, Jag and Mel recruit their friend Tanya and her gang of rough women. The search begins, neither side will give up, revenge will be taken!

25 years later after the events of Samurai Cop (1991), Detective Frank Washington is forced to team up with his long estranged partner Joe Marshall to solve a series of assassinations being committed by a secret group of female vigilante killers.